What is the Undiagnosed Diseases Network?

The Undiagnosed Diseases Network (UDN) is a research study that is funded by the National Institutes of Health Common Fund . Its purpose is to bring together clinical and research experts from across the United States to solve the most challenging medical mysteries using advanced technologies.

Through this study, we hope to both help individual patients and families and contribute to the understanding of how the human body works.

Who Is in the Network?

The UDN is made up of a Coordinating Center, Clinical Sites, and Core Facilities (“Cores”).

The Coordinating Center, which coordinates the work of the UDN, is based at the Department of Biomedical Informatics at Harvard Medical School.

The Clinical Sites, where UDN participants are evaluated, are at the Baylor College of Medicine, Duke Medicine with Columbia University Medical Center, Harvard Teaching Hospitals (Brigham and Women’s Hospital, Boston Children’s Hospital, Massachusetts General Hospital), the National Institutes of Health (NIH) Clinical Center, Stanford Medical Center, University of California at Los Angeles Medical Center, and Vanderbilt University Medical Center.

The two Sequencing Cores, where genetic testing for the UDN is performed, are at the Baylor College of Medicine and HudsonAlpha with Illumina.

In the near future, additional components will be added to the UDN. For example, the Model Organisms Screening Center will help the network to understand how specific genetic changes might contribute to disease by studying those changes in other organisms. The Metabolomics Core will provide the UDN with advanced tools to study biological markers that might be related to disease.

How Can I Apply to be a UDN Participant?

You can visit our Apply page to learn more and begin the UDN application process.

Top of page