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Our Current Research

Model Organisms

The Model Organisms Screening Center (MOSC) for the Undiagnosed Diseases Network (UDN) is composed of two Centers that use fruit fly (Drosophila melanogaster), nematode worm (Caenorhabditis elegans) and zebrafish (Danio rerio) genetics and biology to tackle rare and undiagnosed diseases.

Genes of interest

WRNIP1 PRDM16 PIK3CD MED13L BSN MED14

Meet Our Participants


The participant began experiencing chronic constipation at age 6. Testing identified GI issues (gastrointestinal dysmotility) and he was treated with a cecostomy tube at 8 years old. Since then, his constipation has gotten progressively worse and he has not been able to be weaned off of the cecostomy tube. Some … read more

The participant was healthy until age 18. At this time, he was hospitalized for a severe rash on his hands, feet, and torso. He was suspected to have hand, foot, mouth disease. After this hospitalization and receiving the Gardasil shot, he continued to experience fatigue. At age 22, the participant … read more

Shortly after birth, the patient was found to have pyloric stenosis, a condition in which muscles block food from entering the small intestine. She underwent surgery to correct this at 9 weeks. Currently she has reduced functioning of her stomach and intestines (reduced gastric and intestinal motility) and constipation. She … read more

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