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Our Current Research

Model Organisms

The Model Organisms Screening Center (MOSC) for the Undiagnosed Diseases Network (UDN) is composed of two Centers that use fruit fly (Drosophila melanogaster), nematode worm (Caenorhabditis elegans) and zebrafish (Danio rerio) genetics and biology to tackle rare and undiagnosed diseases.

Genes of interest

PRDM16 PIK3CD MED13L BSN MED14 MARS1

Meet Our Participants


The participant has had trouble walking her entire life.  As a child, she used foot braces and started using a cane when she was 35. In her 40s, she started having arm weakness as well. Currently she has numbness and sharp burning pain in her hands and feet. She is … read more

The participant was in excellent health until about three years ago when she started experiencing severe bilateral vocal cord spasms. This came on very suddenly and impacted her ability to breathe. She underwent an emergency tracheostomy and, since this procedure, her breathing has improved greatly. Over the past few years, … read more

At a young age, the participant began experiencing chronic constipation and vertigo. His vertigo often included lightheadedness, dizziness, blurred vision and ringing in his ears (tinnitus) when he would move from sitting to standing. He was also found to have small and non-reactive pinpoint pupils. At age 39, the participant’s … read more

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