Every year hundreds of patients face uncertainty when healthcare providers are unable to discover the cause for their symptoms.
The Undiagnosed Diseases Network (UDN) is a research study backed by the National Institutes of Health that seeks to provide answers for patients and families affected by these mysterious conditions.
Model Organisms
The Model Organisms Screening Center (MOSC) for the Undiagnosed Diseases Network (UDN) is composed of two Centers that use fruit fly (Drosophila melanogaster), nematode worm (Caenorhabditis elegans) and zebrafish (Danio rerio) genetics and biology to tackle rare and undiagnosed diseases.
Publications

The participant was born at 37 weeks weighing 3lbs 13oz. He spent 19 days in the NICU due to feeding difficulties. He began to experience recurrent upper and lower respiratory tract infections at 6 months and was later identified to have abnormal movement of the cilia (abnormal ciliary motility), upper … read more

During pregnancy, the participant was found to have poor growth (intrauterine growth restriction) and there was more amniotic fluid than normal (polyhydramnios). After birth, he had trouble breathing and low Apgar scores. He was found to have multiple skeletal anomalies (metaphyseal widening, tibial and fibular bowing, cervical spinal canal stenosis) … read more

The participant’s parents became concerned with his development when he was about 3-4 years old. At this time, his speech was delayed and he was learning a bit slower than other children in school. He was able to graduate from high school, but had difficulty with college level work. Otherwise … read more
