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Our Current Research

Model Organisms

The Model Organisms Screening Center (MOSC) for the Undiagnosed Diseases Network (UDN) is composed of two Centers that use fruit fly (Drosophila melanogaster), nematode worm (Caenorhabditis elegans) and zebrafish (Danio rerio) genetics and biology to tackle rare and undiagnosed diseases.

Genes of interest

WRNIP1 PRDM16 PIK3CD MED13L BSN MED14

Meet Our Participants


The participant was delivered via C-section at 35 weeks gestation. The pregnancy was complicated by persistent nausea and vomiting (hyperemesis gravidarum), as well as decreased fetal movements. In early infancy, she exhibited sweating with feeding which led to the detection of an irregular heartbeat (Wolff-Parkinson-White syndrome), which was treated with … read more

The participant was delivered via C-section due to breech presentation. She was noted to have decreased fetal movements during the pregnancy. At birth, the participant had a good Apgar score but did not cry well. She rarely cried during infancy. Rather than being fed on demand, the participant was fed … read more

The participant was born prematurely at 33 weeks after she was diagnosed with IUGR at 27 weeks. She had a gap between her larynx and esophagus (laryngeal cleft) which was later repaired. During infancy, she experienced episodes of retching and choking, which lead to low blood oxygen levels and occasionally … read more

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