Every year hundreds of patients face uncertainty when healthcare providers are unable to discover the cause for their symptoms.
The Undiagnosed Diseases Network (UDN) is a research study backed by the National Institutes of Health that seeks to provide answers for patients and families affected by these mysterious conditions.
Model Organisms
The Model Organisms Screening Center (MOSC) for the Undiagnosed Diseases Network (UDN) is composed of two Centers that use fruit fly (Drosophila melanogaster), nematode worm (Caenorhabditis elegans) and zebrafish (Danio rerio) genetics and biology to tackle rare and undiagnosed diseases.
Publications

The participant began experiencing chronic constipation at age 6. Testing identified GI issues (gastrointestinal dysmotility) and he was treated with a cecostomy tube at 8 years old. Since then, his constipation has gotten progressively worse and he has not been able to be weaned off of the cecostomy tube. Some … read more

The participant was healthy until age 18. At this time, he was hospitalized for a severe rash on his hands, feet, and torso. He was suspected to have hand, foot, mouth disease. After this hospitalization and receiving the Gardasil shot, he continued to experience fatigue. At age 22, the participant … read more
Shortly after birth, the patient was found to have pyloric stenosis, a condition in which muscles block food from entering the small intestine. She underwent surgery to correct this at 9 weeks. Currently she has reduced functioning of her stomach and intestines (reduced gastric and intestinal motility) and constipation. She … read more
