Solving Medical Mysteries
Through Team Science

About Us


The Undiagnosed Diseases Network (UDN) is a research study funded by the National Institutes of Health. Its purpose is to bring together clinical and research experts from across the United States to solve the most challenging medical mysteries using advanced technologies.

Through this study, we hope to both help individual patients and families living with the burden of undiagnosed diseases, and contribute to the understanding of how the human body works.


The UDN is made up of a Data Management Coordinating Center, Clinical Sites, and Core Facilities.

The Data Management Coordinating Center, which coordinates the work of the UDN, is based at Harvard Medical School, Morehouse School of Medicine, University of Alabama at Birmingham, University of Utah, Washington University in St. Louis, and Stanford University.

The Clinical Sites, where UDN participants are evaluated, are located in 15 locations across the United States:

Baylor clinical siteBaylor College of Medicine/Texas Children’s Hospital/Baylor St. Luke’s Medical CenterHouston, TX
CHOP-UPenn clinical site *closed to new applications (cerrado a nuevas solicitudes)*The Children’s Hospital of Philadelphia/University of PennsylvaniaPhiladelphia, PA
Duke clinical siteDuke Undiagnosed Diseases ProgramDurham, NC
Harvard clinical site *closed to new applications (cerrado a nuevas solicitudes)*Mass General Brigham/Boston Children’s Hospital Undiagnosed Diseases ProgramBoston, MA
Mayo clinical siteMayo ClinicRochester, MN
Miami clinical siteUniversity of Miami Miller School of MedicineMiami, FL
NIH Undiagnosed Diseases Program (UDP) clinical siteNIH Undiagnosed Diseases ProgramBethesda, MD
Stanford clinical siteStanford Center for Undiagnosed DiseasesPalo Alto, CA
UAB clinical siteUAB Undiagnosed Diseases ProgramBirmingham, AL
UCI-CHOC clinical site *closed to new applications (cerrado a nuevas solicitudes)*University of California Irvine/Children’s Hospital of Orange CountyOrange County, CA
UCLA clinical site *closed to new applications (cerrado a nuevas solicitudes)*California Center for Rare Diseases at UCLALos Angeles, CA
University of Washington and Seattle Children’s Pacific Northwest clinical siteUniversity of Washington School of Medicine/Seattle Children’s HospitalSeattle, WA
Utah clinical site *closed to new applications (cerrado a nuevas solicitudes)*University of Utah Intermountain West Clinical SiteSalt Lake City, UT
Vanderbilt clinical site *closed to new applications (cerrado a nuevas solicitudes)*Potocsnak Center for Undiagnosed and Rare Disorders at Vanderbilt University Medical CenterNashville, TN
WUSTL clinical siteWashington University in St. Louis Undiagnosed Diseases Network Clinical SiteSt. Louis, MO

At the Clinical Sites, doctors and healthcare providers, like neurologists, immunologists, nephrologists, endocrinologists, and geneticists, work together to help find the cause of participant symptoms.

The Sequencing Core, which provides sequencing services for the UDN, is at Baylor College of Medicine.

The Model Organisms Screening Center, located at Baylor College of Medicine, Washington University in St. Louis, and University of Oregon, helps the network understand how specific genetic changes contribute to disease by studying these changes in other organisms. The Metabolomics Core, located at the Mayo Clinic in Rochester, MN, provides the UDN with advanced tools to study biological markers that might be related to disease.


UDN Quarterly Report – Spring 2024
UDN Quarterly Report – Winter 2024
UDN Quarterly Report – Fall 2023
UDN Quarterly Report – Summer 2023
UDN Quarterly Report – Spring 2023
UDN Quarterly Report – Winter 2023
UDN Quarterly Report – Fall 2022
UDN Quarterly Report – Summer 2022
UDN Quarterly Report – Spring 2022
UDN Quarterly Report – Winter 2022
UDN Quarterly Report – Fall 2021
UDN Quarterly Report – Summer 2021
UDN Quarterly Report – Spring 2021
UDN Quarterly Report – Winter 2021
UDN Quarterly Report – Fall 2020