Solving Medical Mysteries
Through Team Science

Funding Opportunities

Open Opportunities

Information: Clinical Research Support Core Subawards – February 2024

Application: https://redcap.wustl.edu/redcap/surveys/?s=7MDDDKA4DNRP3XLJ

Contact: dmccresearchcore@wustl.edu

Subawards will be funded to support X01, U01, and Affiliate UDN Sites and collaborators in: (1) site coordination or data submission, (2) confirming a diagnosis with metabolomics or gene function studies, and (3) obtaining pilot data to facilitate future, larger research studies.

Key Dates

Call for Subawards posted: December 1, 2023
MOSC Summary for QC review for gene function and cell culture proposals: January 1, 2024
Proposal due: February 1, 2024
Awards announced: March 1, 2024
Earliest start date: April 1, 2024
Project period: April 1, 2024-March 31, 2025

Submission Instructions

Final proposals must be submitted by 5:00 PM EST on February 1, 2024. Proposal received after this deadline will not be reviewed. Please adhere to the Format of Subawards described in the attached Subawards Guidelines document. All proposals must be submitted via the WUSTL REDCap site.

Contact Information

If you have questions about the proposal requirements, please email fcole@wustl.edu.

Closed Opportunities

Gene Function Studies – January 2019

Gene Function Studies – September 2019

Gene Function Studies – September 2020

Clinical Research Support Core Subawards – October 2023

Funded Projects
Institution(s)Principal Investigator(s)Project TitleProject Start Date
The Trustees of Indiana UniversityStephanie Ware, MD, PhDClinical Site Operations Support for Indiana Undiagnosed Rare Disease ClinicSeptember 1, 2023
Pacific Northwest UDN (University of Washington/Seattle Children’s Hospital)Gail Jarvik, MD, PhD (UDN site PI), Andrew B. Stergachis, MD, PhD (project PI)Application of Multi-Ome Long-Read Sequencing to Unsolved UDN CasesSeptember 1, 2023
The Board of Trustees of The University of Alabama for The University of Alabama at BirminghamBruce Korf, MD, PhDImproving Efficiency, Access, and Diversity of UAB UDP Patient EvaluationsSeptember 1, 2023
Regents of the University of California, Los AngelesStanley F. Nelson, MD, and Julian Martinez, MD, PhDGene Function Studies of Rare Variants in Nove L and Candidate Genes Associated With Mitochondrial FunctionSeptember 1, 2023
University of UtahLorenzo Botto, MD (UDN site PI), Jihyun Song, PhD (project PI)Primary and Secondary Erythrocytosis Caused by a Mutation in mRNA Cap Methyltransferase 1 (CMTR1)September 1, 2023
Vanderbilt UniversityRizwan Hamid, MD (UDN site PI), Lisa Bastarache, MS (project PI), and Rory Tinker, MD (project PI)Developing a bioinformatic pipeline to interpret variants of unknown significance within the UDN using BioVUSeptember 1, 2023
Medical College of WisconsinDonald Basel, MDUDN Clinical Research Support Core Year 1 SubawardSeptember 1, 2023
Washington University in St. LouisPatricia I. Dickson, MDLong-read RNA Sequencing to Increase Diagnostic SuccessSeptember 1, 2023
Baylor College of MedicineHugo J. Bellen, DVM, PhD and Scott Barish, PhDUncovering the molecular mechanisms of the chromatin remodeler BICRA in the nervous systemJuly 1, 2021
Monash UniversityRobert Bryson-Richardson, PhDIdentifying the mechanism of, and therapies for, UBA5 epileptic encephalopathy July 1, 2021
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and Massachusetts General HospitalTeresa Dunn, PhD and Florian Eichler, MDThe mechanistic basis of developmental delay due to mutations in SPTSSAJuly 1, 2021
Washington University in St. LouisLilianna Solnica-Krezel, PhDUsing zebrafish and human pluripotent stem cells to evaluate pathogenicity and define disease mechanisms for a ENY2 variant (p.K30Rfs*6)July 1, 2021
University of Alabama at BirminghamSummer Thyme, PhDUndiagnosed Diseases Network Gene Function Study NSD2July 1, 2021
Rutgers UniversityChing-On Wong, PhDDelineating the signaling pathways associated with a disease-causing gain-of-function CLCN7 variantJuly 1, 2021
The University of Texas MD Anderson Cancer CenterSwathi Arur, PhDTo understand the mechanism of action of the damaging DROSHA variant p.D1219G using C. elegansJuly 1, 2020
Baylor College of MedicineHugo J. Bellen, DVM, PhD Exploring the role of WDR37 in a neurological syndrome with striking similarities to Schuurs-Hoeijmakers syndromeJuly 1, 2020
Washington University in St. LouisJohn A. Cooper, MD, PhDUsing zebrafish as an animal model to evaluate pathogenicity and define disease mechanisms for a CARMIL3 variant (p.Gln928Glu)July 1, 2020
University of California, DavisDaniel Starr, PhDA humanized C. elegans model to study KLC4 kinesin light
chain in disease
July 1, 2020
University of OregonMonte Westerfield, PhDUndiagnosed Diseases Network Gene Function Study PAPSS1July 1, 2020
Baylor College of MedicineShinya Yamamoto, PhDExploring the molecular mechanisms of Glutaminase-related neurological diseasesJuly 1, 2020
Baylor College of MedicineHugo J. Bellen, DVM, PhD Understanding the role of IRF2BPL in neurological diseaseJuly 1, 2019
Baylor College of MedicineLindsay Burrage, MD, PhDER stress in TANGO2-related metabolic encephalopathy and arrhythmiasJuly 1, 2019
University of IowaLori Wallrath, PhDMechanisms of TMEM43 muscle diseaseJuly 1, 2019
University of MichiganPaul C. Tang, MD, PhDElucidation of the Mechanism of Disease in a TAX1BP3 gene variant associated with human Arrhythmogenic Right Ventricular CardiomyopathyJuly 1, 2019
University of OregonMonte Westerfield, PhDUndiagnosed Diseases Network Gene Function Study MAST2July 1, 2019
Washington University in St. LouisKristen Kroll, PhDUsing human pluripotent stem cell models to evaluate pathogenicity and define
disease mechanisms for a ZNF292 variant found in a UDN participant
July 1, 2019