On this page, you will find information about a genetic change that was identified in a UDN participant. We are trying to find others with the same or similar condition.

Sharing information on this website is not a requirement of UDN participation. Only descriptions about participants who give explicit consent will appear here.

A change in this gene was identified in a UDN participant with prune belly syndrome and strokes due to disease of the arteries in the brain (arteriopathy) (read full description).

Date of Report

Sep 21, 2022

Full Name

Micro RNA 145

Chromosome 5 (5q32)


MIR145 encodes for microRNA-145. MicroRNAs bind to complementary target mRNAs, which prevents the mRNA from being translated or cleaved. MicroRNA-145 has been shown to be important for the proper development and function of smooth muscle cells (Riches-Susman, 2021).

Database Links

GeneCards: MIR145

MedlinePlus Genetics: MIR145

NCBI Gene: 406937

OMIM: 611795

Clinical Significance

A change in this gene was identified in a UDN participant.

Gene MIR145
Inheritance Pattern Autosomal dominant
Position (hg19) chr5:g.148810226C>A
Transcript NR_029686.1
DNA Change n.18C>A
Protein Change N/A
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