This Center, located in Boston, MA, is a collaboration between Boston Children’s Hospital, Brigham and Women’s Hospital, and Massachusetts General Hospital. Our goal is to offer new hope to patients who suffer from diseases and symptoms that have eluded diagnosis.  Each patient will consult with a team of experts who will provide a detailed clinical evaluation, cutting-edge genetic and genomic analysis, environmental exposure analysis, proteomics, metabolomics, systems biology and network medicine analysis.

The center will tap the three hospitals’ strengths, such as Brigham and Women’s expertise in cardiac genetics and Boston Children’s knowledge of neurogenetics and rare diseases. The clinical team is made up of world class experts that are recognized globally as leaders in their individual fields of medicine. They are at the forefront of cutting-edge research, clinical technologies, and genetic sequencing that spans across adult and pediatric specialties and subspecialties. Patients in the program will benefit from our doctors’ medical knowledge and translational research, while receiving the highest level of interdisciplinary clinical care.




Harvard Clinical Site, 77 Avenue Louis Pasteur, Boston, MA  02115 HarvardUDN@partners.org


‘Most challenging patients’ hope to get diagnoses from medical experts  
July 21, 2016
WCVB Channel 5, Boston

An online portal for undiagnosed patients
September 17, 2015
Vector, Boston Children’s Hospital’s science and clinical innovation blog

Calling All Gene Detectives: Solve Diagnosis Mysteries To Win Contest, Play Role In Film
June 19, 2015
WBUR’s CommonHealth

Using DNA, researchers vie for diagnosis
May 29, 2015
Boston Herald

New ‘Undiagnosed Disease’ Center Funded by NIH
Harvard Medical School News

Solving medical mysteries: The Undiagnosed Disease Network
Vector, Boston Children’s Hospital’s science and clinical innovation blog

Boston hospitals get rare mission
Boston Herald

Undiagnosed-diseases center to open in Boston
Boston Globe